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FDA peptide compounding plan would reportedly require purity and identity certification and adverse-event reporting

Bloomberg News reported on 22 October 2026, citing people familiar with the matter, that the FDA peptide compounding proposal under White House review includes more patient protections than initially expected.

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Citizen petition asks FDA not to allow compounding of the seven peptides reviewed by its July advisory committee

The Partnership for Safe Medicines (PSM), a drug-safety advocacy group, has filed a citizen petition asking FDA not to allow compounding with any of the seven peptide bulk drug substances its Pharmacy Compounding Advisory Committee (PCAC) considered on 23-24 July 2026.

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FDA peptide compounding notice: White House review log now lists six outside meetings, text still unpublished

As of 24 October 2026, the White House Office of Information and Regulatory Affairs (OIRA) still lists the FDA notice "Interim Access Policy for Compounding Using Certain Peptides" (RIN 0910-ZD94) as pending review, as it has since it was received on 14 October.

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Time-resolved AFM shows how a second peptide crystal layer nucleates on top of the first

An open-access Advanced Functional Materials study published October 22, 2026 used time-resolved atomic force microscopy to follow how a second layer of peptide crystals nucleates and grows on a first peptide layer on graphite.

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Phage display screen finds short peptides that block ice nucleation, and an alanine swap makes one stronger

Researchers at Kansai University in Suita, Japan, reported in the Journal of Peptide Science, published online on 22 October, a phage display screen for peptides with anti-ice-nucleation activity.

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Benchmark finds AI cofolding models can place a ligand correctly while mispredicting the protein's conformation

Researchers at Freie Universität Berlin reported in the Journal of Chemical Information and Modeling, published online on 20 October, a benchmark of four AI cofolding models that predict protein-ligand complexes: AlphaFold3, RoseTTAFold3, Boltz-2 and Chai-1.

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Cryo-EM captures a single-module peptide synthetase mid-reaction, revealing a built-in Pictet–Spengler domain

A Journal of the American Chemical Society study published October 20, 2026 reports a 2.76 Å cryo-EM structure of SacC, a single-module nonribosomal peptide synthetase, trapped mid-reaction with a partner protein and a covalent chemical probe.

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CasanovoGUI puts deep-learning de novo peptide sequencing in a point-and-click desktop app

A Journal of Proteome Research paper published October 19, 2026 presents CasanovoGUI, an open-source desktop app that runs the Casanovo deep-learning model for de novo peptide sequencing on Windows, macOS and Linux without command-line setup.

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CE-guided diaPASEF acquisition raises protein identifications from picogram and single-cell samples

Researchers at the University of Maryland reported in Analytical Chemistry, published online on 20 October, electrophoresis-correlative diaPASEF (Eco-diaPASEF), a data-acquisition strategy that improves protein coverage in low-input and single-cell proteomics by capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS).

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NMR and DFT show peptide thioimidates keep a near-equal cis/trans balance regardless of flanking residues

Researchers at Iowa State University reported in Organic Letters, published online on 20 October, a systematic study of the structural factors that control isomerization of thioimidates in the peptide backbone.