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A fungal GPCR senses farnesol to keep spores dormant, and soil bacteria can tip the switch

Researchers at Northwest A&F University in Yangling, China, with a collaborator at Purdue University, reported in Nature Microbiology, published online on 19 October, that a G-protein-coupled receptor (GPCR) named Rsd1 acts as a sensor that controls whether spores of the wheat pathogen Fusarium pseudograminearum stay dormant or germinate.

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An immobilized thiol catalyst moves native chemical ligation into continuous flow

A JACS Au study published October 17, 2026 describes native chemical ligation run in continuous flow with an immobilized thiol catalyst, compatible with inline desulfurization, for synthetic peptides up to 84 amino acids long.

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Bacterial defence systems disable phage tail fibres so that newly made virus particles cannot infect

Researchers at West China Hospital, Sichuan University, in Chengdu reported in Nature Communications, published online on 19 October, two bacterial anti-phage defence systems that act directly on a viral structural protein.

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SLIM ion mobility-MS workflow raises peptide identifications more than tenfold over single-shot LC-MS

Researchers at Pacific Northwest National Laboratory reported in the Journal of Proteome Research, published online on 18 October, fracSLIM, a high-throughput proteomics workflow that combines offline peptide fractionation with high-resolution ion mobility spectrometry-mass spectrometry (IMS-MS) based on structures for lossless ion manipulation (SLIM).

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Physics-based pocket design gives de novo proteins pre-organised binding sites for chromophores

Researchers at the University of Bristol, with collaborators at the NNF Center for Protein Design at the University of Copenhagen, the University of Sheffield and the University of Manchester, reported in Nature Communications, published online on 19 October, a rapid physics-based computational method for building small-molecule binding pockets into de novo designed proteins.

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FDA's interim peptide compounding policy reaches White House review, with its text not yet public

An FDA notice on compounding with certain peptides is under OIRA review. What the public record shows, what it does not, and how it links to July.

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Online 2D nanoLC and capillary electrophoresis-MS platform triples proteoform identifications

Researchers at Aalen University and Kiel University in Germany reported in Analytical Chemistry, published online on 14 October, a comprehensive online coupling of nanoflow liquid chromatography with capillary zone electrophoresis-mass spectrometry (2D nanoLCxCZE-MS) for deep top-down proteomics.

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HDOCK-Multimer combines docking and combinatorial assembly to predict structures of large protein complexes

Researchers at Huazhong University of Science and Technology in Wuhan, China, reported in Nature Computational Science, published online on 14 October, HDOCK-Multimer (HDM), an open framework for predicting the three-dimensional structures of large protein assemblies.

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De novo designed cysteine proteases cut peptide bonds at chosen sequences using folds unlike natural enzymes

Researchers at the University of Washington's Institute for Protein Design, with collaborators at ETH Zurich, KAIST, Stanford University, the University of Oxford, the University of Cambridge and Lawrence Berkeley National Laboratory, reported in Nature, published online on 14 October, the de novo computational design of enzymes that hydrolyse the peptide backbone using an activated cysteine nucleophile.

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Tunable glycine chemistry singles out Staphylococcus aureus in laboratory and mouse models

Researchers at the Indian Institute of Science Education and Research (IISER) Bhopal and collaborating institutes reported in Nature Communications on 5 October an electronically tunable chemical method that selectively modifies N-terminal glycine, a low-frequency molecular signature in peptides and proteins.