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Shorter HMGB1-derived peptides separate anti-biofilm and anti-NET activity in laboratory assays

Researchers at the Abigail Wexner Research Institute at Nationwide Children's Hospital and Ohio State University reported in Frontiers in Immunology, published on 16 October, a structure-based minimisation of a 97-amino-acid peptide derived from the B box of the protein HMGB1.

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Genome survey finds 36 putative antimicrobial peptides in the malaria mosquito, two active against parasites in vitro

Researchers at the Johns Hopkins Bloomberg School of Public Health in the United States reported in npj Antimicrobials and Resistance, published on 13 October, a genome-wide search for antimicrobial peptides (AMPs) in Anopheles gambiae, the main mosquito vector of malaria.

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ScopeNovo reranks de novo peptide sequencing candidates by spectrum-to-spectrum similarity

Researchers at the City University of Hong Kong reported in Bioinformatics, published online on 15 October, ScopeNovo, a method for de novo peptide sequencing from tandem mass spectra.

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One peptide capping ligand builds three bimetallic nanoparticle catalysts to test metal composition effects

Researchers at the University of Miami and the Air Force Research Laboratory in the United States reported in ACS Applied Nano Materials, published online on 14 October, a set of peptide-capped bimetallic nanoparticles designed to separate the effect of metal composition from that of the surface ligand.

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Pep2Net unifies 52 peptide databases with a cross-attention model for multi-task peptide prediction

Researchers at Hunan University, Central South University, the University of Electronic Science and Technology of China and Shenzhen University of Advanced Technology reported in Genome Biology, published online on 14 October, Pep2Net, a platform for computational peptide characterisation.

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Short charged elastin-like peptide tags curb insoluble aggregation of scFv-based proteins

Researchers at the Gwangju Institute of Science and Technology in South Korea reported in Biomacromolecules, published online on 14 October, short Charge-Laden Elastin-like Polypeptide-based Aggregation Reduction (CLEAR) tags tested on two aggregation-prone scFv-based Albubody proteins.

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Open MONDE·T database maps 1,210 non-standard amino acids across 23,149 Protein Data Bank structures

Max Planck researchers released MONDE·T, a free database and webserver cataloging 1,210 non-standard amino acids and 724 synthetic peptide components found in 23,149 Protein Data Bank structures, with backbone-angle plots, 3D views and CSV downloads.

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Core-peptide length steers atropopeptide cross-linking and an excision route to diketopiperazine alkaloids

Researchers at Goethe University Frankfurt in Germany and ETH Zurich in Switzerland reported in the Journal of the American Chemical Society, published online on 13 October, that core-peptide length, rather than sequence alone, can determine which cross-linking pattern an atropopeptide-forming cytochrome P450 installs.

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Dual-functional directing group enables a general synthesis of tryptophan-crosslinked macrocyclic peptides

Researchers at Princeton University in the United States reported in Nature Synthesis, published online on 13 October, a general chemical route to tryptophan-crosslinked macrocyclic peptides using rhodium-catalysed intramolecular transannular macrocyclization.

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Photocatalytic tetrapeptides drive enantioselective visible-light transformations under 750 daltons

Researchers at the Technical University of Munich and Helmholtz Munich in Germany reported in Nature Synthesis, published online on 12 October, photocatalytic tetrapeptides that combine substrate recognition and triplet-energy photochemistry in a molecule weighing less than 750 daltons.