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Samsung Peptide's provisional tender result for PolyPeptide clears the minimum acceptance hurdle

PolyPeptide says Samsung Peptide's provisional interim tender result shows about 88% acceptance, clearing the minimum-rate condition subject to confirmation.

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PepOpt applies interpretable machine learning to peptide sequences that include noncanonical amino acids

Researchers affiliated with Texas Tech University and with Discovery Chemistry at Merck & Co., Inc. reported in npj Drug Discovery, published online on 12 October, PepOpt, an interpretable machine-learning framework for peptide lead optimisation in chemical spaces that include noncanonical amino acids (ncAAs).

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A peptide-like DNA-encoded library expands chemical diversity with in silico building-block guidance

Researchers at Uppsala University, KTH Royal Institute of Technology and the Science for Life Laboratory in Sweden reported in ACS Medicinal Chemistry Letters, published online on 12 October, the design and synthesis of a three-cycle, peptide-like DNA-encoded library (DEL) of 403,200 compounds.

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Open PepAD package designs self-assembling amyloid-forming peptides from predefined backbones

Researchers at North Carolina State University in the United States reported in the Journal of Chemical Information and Modeling, published online on 12 October, a user-facing release of PepAD (Peptide Assembly Design), a Monte Carlo algorithm for designing peptides that self-assemble into amyloid-like structures from predefined amyloid backbones.

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A mass spectrometry workflow targets cyclic peptides and finds two new ones in a marine sponge

Shanghai researchers report in Analytical Chemistry a four-step mass spectrometry workflow that detects, annotates and isolates cyclic peptides. Applied to a marine sponge, it flagged 23 candidates and led to two previously unknown cyclooctapeptides.

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A gold–titania Janus material captures exosomes and enriches modified peptides for mass spectrometry

Researchers at Jilin University in China, with collaborators at SCIEX, reported in Analytical Chemistry, published online on 9 October, an Au–TiO₂ Janus material that combines serum exosome capture with enrichment of two post-translationally modified peptide classes.

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An opsonic peptide speeds clearance of radiation-induced macrophage extracellular traps in cell culture

Researchers at the Feinstein Institutes for Medical Research in the United States reported in Frontiers in Immunology, published online on 12 October, laboratory experiments with an opsonic peptide they call OP18.

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Automated platform assembles and refactors non-ribosomal peptide gene clusters without custom DNA synthesis

Researchers at the Shenzhen Institute of Synthetic Biology (Chinese Academy of Sciences), Jinan University and the University of California, Berkeley reported in Nature Communications, published online on 11 October, an automated platform they call OSAR (One-Step Assembly and Refactoring) for handling large non-ribosomal peptide synthetase (NRPS) biosynthetic gene clusters.

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Simulations map how sequence shapes folding and assembly of glycine-repeat peptides on graphite

Researchers at the Universidad de Talca in Chile, Stanford University and Kansas State University reported in the Journal of Chemical Information and Modeling, published online on 9 October, molecular simulations of cyclic peptides made of glycine-X repeats at the interface between graphite and water.

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A protein found only in Salmonella amplifies the bacterium's response to antimicrobial peptides

Researchers in the Department of Biological Sciences at the University of Alberta in Canada reported in mBio, published online on 9 October, a previously unknown component of the PhoP/PhoQ (PhoPQ) two-component signalling system in Salmonella enterica.