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Chemists automate the azapeptide submonomer method on a standard peptide synthesizer

Chemists in the Department of Chemistry at North Carolina State University in the United States reported in the Journal of Peptide Science, published online on 9 October, an automated version of the submonomer method for making azapeptides.

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WADA's 2027 Prohibited List now names peptides among non-approved substances

WADA's 2027 Prohibited List, in force from 1 January 2027, adds "peptides" to the examples in its S0 non-approved class.

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Experts agree 26 standards for testing computer predictions of peptide–target binding

An international panel coordinated from the Institute of Global Health Innovation at Imperial College London, with contributors including the University of Nebraska Medical Center and the University of Pennsylvania, reported in Frontiers in Bioinformatics, published online on 9 October, a standard framework for evaluating computational predictions of how peptides interact with their targets.

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Acetylating peptide N-termini with acetic anhydride can create an unexpected hydantoin impurity

Process chemists at Ferring Pharmaceuticals in Denmark reported in Organic Process Research & Development, published online on 8 October, previously unreported N-terminal hydantoin and N-acetyl hydantoin impurities that formed while capping peptide N-termini with acetic anhydride under commonly used base and solvent conditions.

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This week's Chemistry Nobel puts mirror-image molecules in focus. Here is what that means for peptide testing

The 2026 Chemistry Nobel recognises work on how one mirror-image form of a molecule can come to dominate. For synthetic peptides, that same chemistry sits behind enantiomeric purity testing, a quality check European guidance describes in detail.

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Ethanol and water replace harsher solvents in a route to pseudoproline dipeptide building blocks

A team at R.

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A newly mapped family of bacterial proteases trims peptides at one chosen site

Researchers at institutions in Shenzhen and Guangzhou, China, including Shenzhen Bay Laboratory and Sun Yat-sen University, reported in the Journal of the American Chemical Society, published online on 8 October, a clade of cyanobactin proteases that process a wide range of peptide substrates while keeping strict selectivity for their recognition sequence.

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Peptide capabilities widen as contract manufacturers expand in India and the US

Two contract manufacturers have announced moves that add peptide capabilities.

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Peptide coatings offer a modular way to tune lipid nanoparticles for mRNA delivery

A team at Tianjin University has reported in Biomacromolecules, published online on 6 October, a modular way to modify lipid nanoparticles (LNPs) after they have been formulated, by coating their surfaces with peptides through physical assembly instead of chemically changing the core lipids.

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US peptide manufacturing capacity grows as two contract manufacturers expand

Two contract development and manufacturing organisations have announced US expansions that include peptide work.