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Catalytic ring-closing chemistry opens a route to strained, atropisomeric cyclic peptides

A team at the Institute of Organic Chemistry and Biochemistry in Prague (IOCB Prague) has reported a catalytic macrocyclization that forms sterically hindered carbon–nitrogen bonds through an intramolecular nucleophilic aromatic substitution (SNAr) reaction.

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A short lipidated peptide breaks an ion-channel partnership and quiets pain-signalling neurons in mouse models

Researchers at Boston Children's Hospital have reported in Cell Reports Medicine that the sodium channel NaV1.8, which helps pain-sensing neurons fire, depends on a scaffolding protein called ankyrin-G (Ank3) to sustain the heightened electrical activity seen in pathological pain.

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Protein language model predicts peptide hormone sequences with high accuracy

A research team has described pLM-HP, a deep-learning framework that predicts whether a given peptide sequence functions as a hormone.

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Peptide API manufacturing capacity: what a major CDMO acquisition signals for the research supply chain

The main acceptance period for Samsung Biologics' all-cash offer to acquire PolyPeptide Group, a Swiss contract manufacturer of peptide active ingredients, is scheduled to close on 12 October 2026.

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Proposed federal bill would direct a VA review and study of peptide therapies

A bill introduced in the US House on 1 September 2026, the PEPTIDES for Veterans Act (H.R. 10212), would direct the Department of Veterans Affairs to review existing regulations and guidance on peptides and report to Congress within 180 days.

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New chemistry builds bicyclic peptide libraries directly on phage

A Texas A&M team has reported PReP-Bicyc, a method for turning peptide libraries displayed on bacteriophage into bicyclic peptides without additives.

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Designed membrane-embedded proteins modulate an innate immune receptor in cell models

Researchers at Scripps Research have designed small synthetic proteins that sit inside the cell membrane and interact with Toll-like receptor 4 (TLR4), an immune sensor that detects bacterial molecules.

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Bacteriostatic Water Explained: Definition, Water Grades and Lot Documentation

What bacteriostatic water is under USP, how it differs from sterile, purified and lab-grade water, and what its lot documentation should show.

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The "Face" Question: What Dermatology Research Says About Skin in the Weight-Drug Era

Facial volume, laxity and a skincare boom: what dermatology reviews and beauty reporting say about skin in the weight-drug era, and what's unproven.

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AI Is Learning to Read Hair: What Algorithms Can and Can't Do in Scalp Research

From trichoscopy algorithms to salon scalp cameras, AI is learning to read hair. What new reviews report, and where the evidence still falls short.